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Bacteroides fragilis toxin

Coverage of Bacteroides fragilis toxin in the Nexus archive.

Earliest in view: Apr 22 · 00:00 UTCMost recent: Apr 22 · 00:00 UTC
Co-mentioned in this coverage
claudin-4topic1E-cadherintopic1CRISPR screeningtopic1colonic epithelial cellstopic1Natureorganization1
Recent coverage
  • SCIENCEApr 22 · 00:00 UTCNATURE NEWS
    A pro-carcinogenic bacterial toxin binds claudin-4 to cleave E-cadherin

    A study published in Nature identifies claudin-4 as a receptor for the pro-carcinogenic toxin from Bacteroides fragilis. The toxin's interaction with claudin-4 on colonic epithelial cells leads to E-cadherin cleavage, disrupting epithelial barriers and causing inflammation.