LDL cholesterol
Coverage of LDL cholesterol in the Nexus archive.
- ‘Revolutionary’ new treatment can lower bad cholesterol by up to 62% — with just one dose
A new treatment has been developed that can reduce bad LDL cholesterol levels by up to 62% with a single dose, potentially lowering the risk of plaque buildup in blood vessels and heart-related complications.
- One-and-done injection can slash 'bad' cholesterol by 60 per cent, according to new study
A one-time injection has been shown to reduce 'bad' cholesterol levels by 60% in a new study, offering a potential breakthrough in managing high cholesterol.
- STAT+: Pharmalittle: We’re reading about a Lilly gene therapy for cholesterol, three new Lilly deals, and more
Eli Lilly's gene therapy reduced cholesterol by 62% in a Phase 1 trial, with no serious adverse events. The company acquired the therapy through its $1 billion buyout of Verve Therapeutics and plans Phase 2 trials. Lilly also agreed to buy three vaccine developers (Curevo, LimmaTech Biologics, and Vaccine Company) in deals totaling up to $4 billion, expanding its focus on infectious diseases.
- STAT+: Eli Lilly says Verve’s gene editor lowers cholesterol levels in early study
Eli Lilly reported a 62% reduction in LDL cholesterol levels in a Phase 1 trial using its gene-editing therapy, VERV-102, acquired from Verve Therapeutics. The therapy showed no serious adverse events, marking a significant safety improvement over Verve's previous shelved candidate. The treatment is positioned as a potential one-time solution for preventing heart disease.
- New treatment cuts bad cholesterol by nearly 50% without statins
Researchers have developed DNA-based molecules that block the PCSK9 protein, reducing LDL cholesterol levels by nearly 50% and offering a statin-free alternative for treating high cholesterol and heart disease.