Streptomyces rimosus

A team of international scientists, including Mexican researcher Nora Vázquez Laslop, discovered manikomycin, an antibiotic that targets a previously unexplored site on bacterial ribosomes, potentially offering new solutions to antibiotic resistance. The compound was isolated from Streptomyces rimosus, a soil bacterium known for producing other antibiotics.

A natural depsipeptide antibiotic called manikomycin, derived from Streptomyces rimosus, targets the E-site of the bacterial large ribosomal subunit. Improved fractionation strategies enabled the discovery of this antibiotic with a novel mechanism.