HEALTHMay 27 · 00:00 UTCNATURE NEWSKatherine M. Aird

αKG-mediated carnitine synthesis drives DNA repair via histone acetylation

The metabolite αKG promotes carnitine synthesis and site-specific histone acetylation, enhancing homologous recombination-mediated DNA repair. This mechanism may offer therapeutic potential for chemoresistant cancers.

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αKGtopiccarnitine synthesistopichistone acetylationtopichomologous recombinationtopicDNA repairtopicchemoresistant cancerstopicNatureorganization

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